Detailed view for Bm1_50650

Basic information

TDR Targets ID: 236084
Brugia malayi, Unc-112 related protein.
Source Database / ID:  GenBank

pI: 6.9389 | Length (AA): 717 | MW (Da): 81855 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00373   FERM central domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0007229   integrin-mediated signaling pathway  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 95 2kmc (A) 0 96 49.00 0 1 0.746102 -0.88
7 91 2lgx (A) 10 94 55.00 0 1 0.81865 -0.73
14 181 3ivf (A) 3 209 16.00 0 1 0.41441 -0.13
84 314 2kc2 (A) 75 198 30.00 0 0.42 -0.514024 2.34
399 530 4f7h (A) 368 499 55.00 0 1 0.9061 -0.85
401 709 1e5w (A) 24 305 17.00 0 0.91 0.387762 1.2
513 695 4f7g (A) 225 400 24.00 0.000000085 0.53 0.40323 0.42
546 687 2i1j (A) 140 268 30.00 0.61 0.35 0.216047 1.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130325)

Species Accession Gene Product
Brugia malayi Bm1_50650   Unc-112 related protein.
Caenorhabditis elegans CELE_C47E8.7   Protein UNC-112
Drosophila melanogaster Dmel_CG7729   Fermitin 2
Drosophila melanogaster Dmel_CG14991   Fermitin 1
Echinococcus granulosus EgrG_000056100   FERM central domain
Echinococcus multilocularis EmuJ_000056100   FERM central domain
Homo sapiens ENSG00000073712   fermitin family member 2
Homo sapiens ENSG00000101311   fermitin family member 1
Homo sapiens ENSG00000149781   fermitin family member 3
Loa Loa (eye worm) LOAG_07078   hypothetical protein
Mus musculus ENSMUSG00000024965   fermitin family homolog 3 (Drosophila)
Mus musculus ENSMUSG00000027356   fermitin family homolog 1 (Drosophila)
Mus musculus ENSMUSG00000037712   fermitin family homolog 2 (Drosophila)
Schistosoma japonicum Sjp_0215820   Protein unc-112, putative
Schistosoma japonicum Sjp_0088320   Fermitin family homolog 2, putative
Schistosoma japonicum Sjp_0087630   Fermitin family homolog 2, putative
Schistosoma mansoni Smp_053420   hypothetical protein
Schmidtea mediterranea mk4.000439.06  
Schmidtea mediterranea mk4.013553.00  
Schmidtea mediterranea mk4.007716.01  

Essentiality

Bm1_50650 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C47E8.7 Caenorhabditis elegans adult lethal wormbase
CELE_C47E8.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_C47E8.7 Caenorhabditis elegans larval lethal wormbase
CELE_C47E8.7 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_50650 (Brugia malayi), Unc-112 related protein.
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